P21 5 mg
$26.40
P21 5 mg – Peptide Hubs
P21 is a synthetic nootropic peptide originally developed to enhance memory, learning, and neurogenesis in preclinical models of brain injury and cognitive decline. It is based on a modified segment of the CNTF (ciliary neurotrophic factor) and penetratin peptide to facilitate blood-brain barrier transport and receptor binding. Peptide Hubs offers P21 in 5 mg high-purity lyophilized form for research use only.
Mechanism of Action
P21 appears to promote neurogenesis, neurotrophic signaling, and synaptic plasticity by enhancing expression of proteins like GAP-43 and BDNF. It also shows potential to regenerate neuronal architecture in animal models of cognitive injury, particularly in aging or chemically-induced brain damage. This review on peptide nootropics discusses emerging candidates like P21 in neurodegeneration and trauma.
Research Applications
- Memory enhancement and cognitive performance studies
- Brain injury and regeneration models
- Alzheimer's and neurodegenerative disorder protocols
- Long-term potentiation and synaptogenesis investigations
P21 is often paired with N-Acetyl Semax Amidate or N-Acetyl Selank Amidate in emotional memory and neuroplasticity studies. For mitochondrial synergy, researchers combine it with Humanin or MOTS-c. DNA repair models frequently include FOX04-DRI in stacked protocols for cellular senescence and neuroprotection.